Clinical relevance of brain atrophy assessment in multiple sclerosis. Implications for its use in a clinical routine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10326077" target="_blank" >RIV/00064165:_____/16:10326077 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10326077
Result on the web
<a href="http://dx.doi.org/10.1080/14737175.2016.1181543" target="_blank" >http://dx.doi.org/10.1080/14737175.2016.1181543</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14737175.2016.1181543" target="_blank" >10.1080/14737175.2016.1181543</a>

Result language
angličtina
Original language name
Clinical relevance of brain atrophy assessment in multiple sclerosis. Implications for its use in a clinical routine
Original language description
Introduction: Brain atrophy measurement in multiple sclerosis (MS) has become an important outcome for determining patients at risk for developing physical and cognitive disability. Areas covered: In this article, we discuss the methodological issues related to using this MRI metric routinely, in a clinical setting. Understanding trajectories of annualized whole brain, gray and white matter, thalamic volume loss, and enlargement of ventricular space in specific MS phenotypes is becoming increasingly important. Evidence is mounting that disease-modifying treatments exert a positive effect on slowing brain atrophy progression in MS. Expert Commentary: While there is a need to translate measurement of brain atrophy to clinical routine at the individual patient level, there are still a number of challenges to be met before this can actually happen, including how to account for biological confounding factors and pseudoatrophy, standardize acquisition and analyses parameters, which can influence the accuracy of the assessments.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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