Moderator's view: Cyclophosphamide in lupus nephritis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10326447" target="_blank" >RIV/00064165:_____/16:10326447 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10326447

Result on the web

<a href="http://dx.doi.org/10.1093/ndt/gfw067" target="_blank" >http://dx.doi.org/10.1093/ndt/gfw067</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ndt/gfw067" target="_blank" >10.1093/ndt/gfw067</a>

Result language

angličtina

Original language name

Moderator's view: Cyclophosphamide in lupus nephritis

Original language description

Mycophenolate mofetil was recently accepted as the effective induction treatment of lupus nephritis, with the potential to replace cyclophosphamide or at least expand our therapeutic armamentarium in patients with this lifelong disease often requiring repeated induction treatment of its relapses. Compared with cyclophosphamide, mycophenolate may be more effective in black patients, and the risk of gonadotoxicity may be significantly lower in mycophenolate-treated subjects. However, experience with mycophenolate in severe lupus nephritis is still limited and we also have insufficient data on the long-term outcome of mycophenolate-treated patients. Treatment with mycophenolate is more expensive than with cyclophosphamide, which may limit its use, especially in low- and middle-income countries. The efficacy of mycophenolate mofetil may be more dependent on the patient's compliance compared with intravenous cyclophosphamide pulses. Low-dose cyclophosphamide remains an effective and relatively safe induction treatment of active lupus nephritis, but to decrease its cumulative toxicity, repeated exposure to cyclophosphamide in relapsing patients should be (if possible) avoided.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nephrology, Dialysis, Transplantation

ISSN

0931-0509

e-ISSN

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Volume of the periodical

31

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

1058-1061

UT code for WoS article

000381214100011

EID of the result in the Scopus database

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