Treatment of proliferative lupus nephritis: a slowly changing landscape

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9002" target="_blank" >RIV/00216208:11110/11:9002 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/11:9002

Result on the web

<a href="http://dx.doi.org/10.1038/nrneph.2010.170" target="_blank" >http://dx.doi.org/10.1038/nrneph.2010.170</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Treatment of proliferative lupus nephritis: a slowly changing landscape

Original language description

Proliferative lupus nephritis is the most severe form of lupus nephritis. Outcomes of this disease are affected by ethnicity, clinical characteristics, irreversible damage on renal biopsy, initial response to treatment and future disease course (for example, the occurrence of renal flares). Initial intensive (induction) treatment of proliferative lupus nephritis is aimed at achieving remission, but optimal duration and intensity are not well defined. A combination of intravenous cyclophosphamide and corticosteroids have been shown to decrease the risk of end-stage renal disease, but are associated with substantial acute toxic effects (such as infections) and chronic toxic effects (such as ovarian failure). In white populations, low-dose cyclophosphamide is a reasonable alternative to high-dose cyclophosphamide as it is similarly effective and associated with less toxicity. Mycophenolate mofetil is as effective as high-dose intravenous cyclophosphamide in terms of inducing remission and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Reviews Nephrology

ISSN

1759-5061

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

96-109

UT code for WoS article

000286727400009

EID of the result in the Scopus database

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