Left Atrial Dysfunction in End-Stage Renal Disease Patients Treated by Hemodialysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10327910" target="_blank" >RIV/00064165:_____/16:10327910 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10327910

Result on the web

<a href="http://dx.doi.org/10.1159/000447500" target="_blank" >http://dx.doi.org/10.1159/000447500</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000447500" target="_blank" >10.1159/000447500</a>

Result language

angličtina

Original language name

Left Atrial Dysfunction in End-Stage Renal Disease Patients Treated by Hemodialysis

Original language description

Background: Repeated inter-dialysis water retention contributes to the development of left ventricular hypertrophy and failure, which is responsible for significant mortality of end-stage renal disease (ESRD) patients. The left atrium has a thin wall, which makes it even more prone to preload changes. In the general population with heart failure with preserved ejection fraction (HFpEF), left atrial function is even worse than that in patients with reduced ejection fraction. We hypothesized that repeated water retention is related to left atrial dysfunction in ESRD patients treated by hemodialysis and that the expected changes would be related to the brain natriuretic peptide (BNP) levels. Methods: Forty six patients were enrolled. Left atrial end-diastolic and end-systolic volumes and left atrial ejection fraction (LAEF) were recorded by echocardiography just before and just after dialysis and then analyzed offline. Moreover, BNP was analyzed also prior to dialysis and after. Effects of dialysis were tested using paired t test and the correlation analysis was applied to test associations. Results: LAEF was inversely related to the dialysis vintage (r = -0.62, p = 0.001) and patient's age (r = -0.48, p = 0.005) and it did not increase after dialysis despite the decrease of left atrial volume. BNP was related to left atrial volume index (r = 0.45, p = 0.019) and to LAEF (r = -0.57, p = 0.003). Conclusions: LAEF is decreased especially in long-term dialyzed patients and does not improve after dialysis despite the decrease of left atrial volume. Inadequate contractility reserve of the left atrium is similar to the non-ESRD patients with HFpEF and might help explain the high prevalence of heart failure in ESRD patients. (C) 2016 S. Karger AG, Basel

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

—

Project

<a href="/en/project/NT14161" target="_blank" >NT14161: Heart failure in chronic kidney disease: the impact of vascular access flow and some other mechanisms</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nephron

ISSN

1660-8151

e-ISSN

—

Volume of the periodical

133

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

6

Pages from-to

169-174

UT code for WoS article

000382743600004

EID of the result in the Scopus database

2-s2.0-84976526067