Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10330105" target="_blank" >RIV/00064165:_____/16:10330105 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10330105
Result on the web
<a href="http://dx.doi.org/10.5603/KP.a2016.0062" target="_blank" >http://dx.doi.org/10.5603/KP.a2016.0062</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5603/KP.a2016.0062" target="_blank" >10.5603/KP.a2016.0062</a>
Alternative languages
Result language
angličtina
Original language name
Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype
Original language description
Background and aim: To study relationships between endothelial dysfunction (ED) and coronary atherosclerosis derived from intravascular ultrasound (IVUS) and virtual histology (VH). Methods: Endothelial dysfunction was examined by EndoPAT system (Itamar Medical) in 56 patients who underwent IVUS and VH (Volcano corp.). Reactive hyperaemia index (RHI) < 2 was used for definition of ED. IVUS sequences were divided into 5 mm-long non-overlapping and adjacent vessel segments. Plaque phenotype was determined for each frame and 5 mm vessel segment was labeled according to highest frame score (from 0 for "no lesion" to 5 for "thin cap fibroatheroma; TCFA"). Results: IVUS-VH data were collected from 41 patients suitable for three-dimensional analysis. Patients with ED exhibited larger plaque burden than those without ED (0.46 +- 0.08 vs. 0.39 +- 0.07, p = 0.014), smaller lumen area (8.59 +- 2.19 vs. 11.90 +- 3.50, p = 0.016), higher plaque risk score (2.82 +- 1.18 vs. 1.84 +- 0.90, p = 0.012), and higher number of TCFA frames (0.36 +- 0.22 vs. 0.22 +- 0.16, p = 0.038). Relative amounts of fibrous tissue correlated positively with RHI (p = 0.034, r = 0.33). The numbers of fibroatheromas and calcified plaques correlated with RHI inversely (r = -0.34, p = 0.031 and r = -0.32, p = 0.044, respectively). Conclusions: Endothelial dysfunction correlates with severity and phenotype of coronary lesions and can contribute to non-invasive detection of individuals with higher risk of cardiovascular events.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LH12053" target="_blank" >LH12053: The prediction of extension and risk profile of coronary atherosclerosis and their changes during lipid-lowering therapy based on non-invasive techniques.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Kardiologia Polska
ISSN
0022-9032
e-ISSN
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Volume of the periodical
74
Issue of the periodical within the volume
12
Country of publishing house
PL - POLAND
Number of pages
7
Pages from-to
1485-1491
UT code for WoS article
000393078300004
EID of the result in the Scopus database
2-s2.0-85008703762