Plaque volume and plaque risk profile in diabetic vs. non-diabetic patients undergoing lipid-lowering therapy: a study based on 3D intravascular ultrasound and virtual histology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F17%3A10366268" target="_blank" >RIV/00064165:_____/17:10366268 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/17:10366268 RIV/00216208:11410/17:10366268 RIV/00023884:_____/12:00007551

Result on the web

<a href="http://dx.doi.org/10.1186/s12933-017-0637-0" target="_blank" >http://dx.doi.org/10.1186/s12933-017-0637-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12933-017-0637-0" target="_blank" >10.1186/s12933-017-0637-0</a>

Result language

angličtina

Original language name

Plaque volume and plaque risk profile in diabetic vs. non-diabetic patients undergoing lipid-lowering therapy: a study based on 3D intravascular ultrasound and virtual histology

Original language description

Background: Coronary atherosclerosis progresses faster in patients with diabetes mellitus (DM) and causes higher morbidity and mortality in such patients compared to non-diabetics ones (non-DM). We quantify changes in plaque volume and plaque phenotype during lipid-lowering therapy in DM versus non-DM patients using advanced intracoronary imaging. Methods: We analyzed data from 61 patients with stable angina pectoris included to the PREDICT trial searching for prediction of plaque changes during intensive lipid-lowering therapy (40 mg rosuvastatin daily). Geometrically correct, fully 3-D representation of the vascular wall surfaces and intravascular ultrasound virtual histology (IVUS-VH) defined tissue characterization was obtained via fusion of two-plane angiography and IVUS-VH. Frame-based indices of plaque morphology and virtual histology analyses were computed and averaged in 5 mm long baseline/follow-up registered vessel segments covering the entire length of the two sequential pullbacks (baseline, 1-year). We analyzed 698 5-mm-long segments and calculated the Liverpool active plaque score (LAPS). Results: Despite reaching similar levels of LDL cholesterol (DM 2.12 +/- 0.91 mmol/l, non-DM 1.8 +/- 0.66 mmol/l, p = 0.21), DM patients experienced, compared to non-DM ones, higher progression of mean plaque area (0.47 +/- 1.15 mm(2) vs. 0.21 +/- 0.97, p = 0.001), percent atheroma volume (0.7 +/- 2.8% vs. - 1.4 +/- 2.5%, p = 0.007), increase of LAPS (0.23 +/- 1.66 vs. 0.13 +/- 1.79, p = 0.018), and exhibited more locations with TCFA (Thin-Cap Fibro-Atheroma) plaque phenotype in 5 mm vessel segments (20.3% vs. 12.5%, p = 0.01). However, only non-DM patients reached significant decrease of LDL cholesterol. Plaque changes were more pronounced in PIT (pathologic intimal thickening) compared to TCFA with increased plaque area in both phenotypes in DM patients. Conclusion: Based on detailed 3D analysis, we found advanced plaque phenotype and further atherosclerosis progression in DM patients despite the same reached levels of LDLc as in non-DM patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/LH12053" target="_blank" >LH12053: The prediction of extension and risk profile of coronary atherosclerosis and their changes during lipid-lowering therapy based on non-invasive techniques.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cardiovascular Diabetology

ISSN

1475-2840

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

December

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

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UT code for WoS article

000417536700001

EID of the result in the Scopus database

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