Pathologic Intimal Thickening Plaque Phenotype: Not as Innocent as Previously Thought. A Serial 3D Intravascular Ultrasound Virtual Histology Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10331208" target="_blank" >RIV/00216208:11110/17:10331208 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/17:10331208
Result on the web
<a href="http://dx.doi.org/10.1016/j.recesp.2016.04.049" target="_blank" >http://dx.doi.org/10.1016/j.recesp.2016.04.049</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.recesp.2016.04.049" target="_blank" >10.1016/j.recesp.2016.04.049</a>
Alternative languages
Result language
angličtina
Original language name
Pathologic Intimal Thickening Plaque Phenotype: Not as Innocent as Previously Thought. A Serial 3D Intravascular Ultrasound Virtual Histology Study
Original language description
Introduction and objectives: Pathologic intimal thickening (PIT) has been considered a benign plaque phenotype. We report plaque phenotypic changes in a baseline/follow-up intravascular ultrasoundbased virtual histology study. Methods: A total of 61 patients with stable coronary artery disease were analyzed from the HEAVEN trial (89 patients randomized between routine statin therapy vs atorvastatin 80 mg and ezetimibe 10 mg) with serial intravascular ultrasound imaging of nonculprit vessels. We compared changes in 693 baseline and follow-up 5-mm long segments in a novel risk score, Liverpool Active Plaque Score (LAPS), plaque parameters, and plaque composition. Results: The PIT showed the highest increase of risk score and, with fibrous plaque, also the LAPS. Necrotic core (NC) abutting to the lumen increased in PIT (22 51.7; P = .0001) and in fibrous plaque (17.9 42.6; P = .004) but decreased in thin cap fibroatheroma (TCFA) (-15.14 52.2; P = .001). The PIT was the most likely of all nonthin cap fibroatheroma plaque types to transform into TCFA at follow-up (11% of all TCFA found during follow-up and 35.9% of newly-developed TCFA), but showed (together with fibrous plaque) the lowest stability during lipid-lowering therapy (24.7% of PIT remained PIT and 24.5% of fibrous plaque remained fibrous plaque). Conclusions: Over the 1-year follow-up, PIT was the most dynamic of the plaque phenotypes and was associated with an increase of risk score and LAPS (together with fibrous plaque), NC percentage (together with fibrous plaque) and NC abutting to the lumen, despite a small reduction of plaque volume during lipid-lowering therapy. The PIT was the main source for new TCFA segments.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NT13224" target="_blank" >NT13224: The prediction of extension and risk profile of coronary atherosclerosis and their changes during lipid-lowering therapy based on non-invasive techniques.</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Revista Española de Cardiología
ISSN
0300-8932
e-ISSN
—
Volume of the periodical
70
Issue of the periodical within the volume
1
Country of publishing house
ES - SPAIN
Number of pages
9
Pages from-to
25-33
UT code for WoS article
000396503600008
EID of the result in the Scopus database
2-s2.0-84995529388