Cystatin C is associated with the extent and characteristics of coronary atherosclerosis in patients with preserved renal function

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10330651" target="_blank" >RIV/00064165:_____/16:10330651 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10330651 RIV/00023884:_____/16:00007717

Result on the web

<a href="http://fb.cuni.cz/file/5824/fb2016a0028.pdf" target="_blank" >http://fb.cuni.cz/file/5824/fb2016a0028.pdf</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Cystatin C is associated with the extent and characteristics of coronary atherosclerosis in patients with preserved renal function

Original language description

Cystatin C (CysC), an endogenous inhibitor of cysteine proteases and a sensitive and accurate marker of renal function, is associated with the severity of coronary atherosclerosis assessed by angiography and future cardiovascular events according to previous studies. We aimed to evaluate the association between CysC levels and coronary plaque volume, composition and phenotype assessed by intravascular ultrasound and intravascular ultrasound-derived virtual histology in patients with preserved renal function. Forty-four patients with angiographically documented coronary artery disease and complete intravascular imaging were included in the study. Patients were categorized into tertiles by CysC levels. Subjects in the high CysC tertile had significantly higher mean plaque burden (48.0 % +- 6.9 vs. 42.8 % +- 7.4, P = 0.029), lower mean lumen area (8.1 mm2 +- 1.7 vs. 9.9 mm2 +- 3.1, P = 0.044) and a higher number of 5-mm vessel segments with minimum lumen area < 4 mm2 (17.9 +- 18.9 vs. 6.8 +- 11.7, P = 0.021) compared to patients in the lower tertiles. In addition, CysC levels demonstrated significant positive correlation with the mean plaque burden (r = 0.35, P = 0.021). Neither relative, nor absolute plaque components differed significantly according to CysC tertiles. The Liverpool Active Plaque Score was significantly higher in the high CysC tertile patients (0.91 +- 1.0 vs. 0.18 +- 0.92, P = 0.02). In conclusion, our study demonstrated a significant association of increased CysC levels with more advanced coronary artery disease and higher risk plaque phenotype in patients with preserved renal function.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

—

Project

<a href="/en/project/LH12053" target="_blank" >LH12053: The prediction of extension and risk profile of coronary atherosclerosis and their changes during lipid-lowering therapy based on non-invasive techniques.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

—

Volume of the periodical

62

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

225-234

UT code for WoS article

000398215600001

EID of the result in the Scopus database

2-s2.0-85013335423