Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10331429" target="_blank" >RIV/00064165:_____/16:10331429 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10331429 RIV/00216208:11130/16:10331429 RIV/00216208:11140/16:10331429 RIV/00216208:11120/16:43911788 RIV/00064173:_____/16:N0000236

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906621/pdf/mco-05-01-0161.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906621/pdf/mco-05-01-0161.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/mco.2016.891" target="_blank" >10.3892/mco.2016.891</a>

Result language

angličtina

Original language name

Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study

Original language description

The present study reports a case of a 44-year-old female patient with a large frontal lobe tumor who underwent surgery using a modern navigation system SonoWand that combines the advantages of a non-frame navigation system with intraoperative real-time ultrasound imaging. The right frontal lobe tumor consisted of two morphologically different sections. A diffuse astrocytoma grade II and a glioblastoma grade IV were identified. These tumors were relatively substantially separated. A 17 p deletion, including TP53, was detected in a diffuse astrocytoma but not in a glioblastoma. EGFR and MDM2 amplifications were detected only in a glioblastoma. Detection of these amplifications is typical for primary glioblastomas. These findings support our assumption of two independent tumors. The KRAS, BRAF and EGFR gene mutations were also detected in a glioblastoma. Such an accumulation of molecular mutations is rare in one tumor. Following oncological treatment the patient was cared for in the oncological center and survived for 15 months after the surgery without any signs of a disease. This is an unusual case, and to the best of our knowledge, is not frequently published in literature.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular and Clinical Oncology

ISSN

2049-9450

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

1

Country of publishing house

GR - GREECE

Number of pages

4

Pages from-to

161-164

UT code for WoS article

000453166300038

EID of the result in the Scopus database

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