All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10331429" target="_blank" >RIV/00064165:_____/16:10331429 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/16:10331429 RIV/00216208:11130/16:10331429 RIV/00216208:11140/16:10331429 RIV/00216208:11120/16:43911788 RIV/00064173:_____/16:N0000236

  • Result on the web

    <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906621/pdf/mco-05-01-0161.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906621/pdf/mco-05-01-0161.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3892/mco.2016.891" target="_blank" >10.3892/mco.2016.891</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study

  • Original language description

    The present study reports a case of a 44-year-old female patient with a large frontal lobe tumor who underwent surgery using a modern navigation system SonoWand that combines the advantages of a non-frame navigation system with intraoperative real-time ultrasound imaging. The right frontal lobe tumor consisted of two morphologically different sections. A diffuse astrocytoma grade II and a glioblastoma grade IV were identified. These tumors were relatively substantially separated. A 17 p deletion, including TP53, was detected in a diffuse astrocytoma but not in a glioblastoma. EGFR and MDM2 amplifications were detected only in a glioblastoma. Detection of these amplifications is typical for primary glioblastomas. These findings support our assumption of two independent tumors. The KRAS, BRAF and EGFR gene mutations were also detected in a glioblastoma. Such an accumulation of molecular mutations is rare in one tumor. Following oncological treatment the patient was cared for in the oncological center and survived for 15 months after the surgery without any signs of a disease. This is an unusual case, and to the best of our knowledge, is not frequently published in literature.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecular and Clinical Oncology

  • ISSN

    2049-9450

  • e-ISSN

  • Volume of the periodical

    5

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GR - GREECE

  • Number of pages

    4

  • Pages from-to

    161-164

  • UT code for WoS article

    000453166300038

  • EID of the result in the Scopus database