Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000236" target="_blank" >RIV/00064173:_____/16:N0000236 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10331429 RIV/00216208:11130/16:10331429 RIV/00216208:11140/16:10331429 RIV/00064165:_____/16:10331429 RIV/00216208:11120/16:43911788
Result on the web
<a href="https://doi.org/10.3892/mco.2016.891" target="_blank" >https://doi.org/10.3892/mco.2016.891</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/mco.2016.891" target="_blank" >10.3892/mco.2016.891</a>

Result language
angličtina
Original language name
Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study
Original language description
The present study reports a case of a 44-year-old female patient with a large frontal lobe tumor who underwent surgery using a modern navigation system SonoWand that combines the advantages of a non-frame navigation system with intraoperative real-time ultrasound imaging. The right frontal lobe tumor consisted of two morphologically different sections. A diffuse astrocytoma grade II and a glioblastoma grade IV were identified. These tumors were relatively substantially separated. A 17 p deletion, including TP53, was detected in a diffuse astrocytoma but not in a glioblastoma. EGFR and MDM2 amplifications were detected only in a glioblastoma. Detection of these amplifications is typical for primary glioblastomas. These findings support our assumption of two independent tumors. The KRAS, BRAF and EGFR gene mutations were also detected in a glioblastoma. Such an accumulation of molecular mutations is rare in one tumor. Following oncological treatment the patient was cared for in the oncological center and survived for 15 months after the surgery without any signs of a disease. This is an unusual case, and to the best of our knowledge, is not frequently published in literature.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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