Predictive role BLVRA mRNA expression in hepatocellular cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10333618" target="_blank" >RIV/00064165:_____/16:10333618 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10333618 RIV/00216208:11130/16:10333618 RIV/00064190:_____/16:N0000082
Result on the web
<a href="http://www.annalsofhepatology.com/revista/numeros/2016/HP166-08-Predective%20%28F_141016V%29_PROTEGIDO.pdf" target="_blank" >http://www.annalsofhepatology.com/revista/numeros/2016/HP166-08-Predective%20%28F_141016V%29_PROTEGIDO.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5604/16652681.1222104" target="_blank" >10.5604/16652681.1222104</a>
Alternative languages
Result language
angličtina
Original language name
Predictive role BLVRA mRNA expression in hepatocellular cancer
Original language description
Introduction and aim. Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor. It is primarily caused by hepatic cirrhosis or chronic viral hepatitis. Hepatic carcinogenesis is associated with increased oxidative stress. Thus, the aim of our study was to assess expression of the genes involved in the homeostasis of oxidative stress in patients with HCC. Material and methods. The study was performed on 32 patients with primary HCC (verified by liver histology in 29 patients) and 27 control subjects (in 11 subjects, liver histology was available either with no or minimal changes in the liver tissue). Gene expressions of heme oxygenase 1 (HMOX1), biliverdin reductase A/B (BLVRA/B), NADPH oxidase 2 (NOX2) and p22phox were analyzed in the liver and peripheral blood leukocytes (PBL) in the subjects. Results. Compared to controls, almost a 3 times higher mRNA level of BLVRA was detected in livers of HCC patients (p = 0.002); while those of BLVRB as well as HMOX1 were unchanged (p > 0.05). In accord with these results in the liver tissue, BLVRA mRNA levels in PBL were also significantly increased in HCC patients (p = 0.012). mRNA levels of NOX2 and p22phox in the liver tissue, although higher in HCC patients, did not differ significantly compared to control subjects (p > 0.05). Nevertheless, NOX2 mRNA level in PBL was significantly higher in HCC patients (p = 0.003). Conclusions. BLVRA mRNA levels in the liver as well as in PBL are significantly higher in HCC patients most likely as a feedback mechanism to control increased oxidative stress associated with HCC progression.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13092" target="_blank" >NT13092: Heme Catabolic Pathway in Chronic Hepatitis C</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annals of Hepatology
ISSN
1665-2681
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
6
Country of publishing house
MX - MEXICO
Number of pages
7
Pages from-to
881-887
UT code for WoS article
000397077900009
EID of the result in the Scopus database
2-s2.0-84995685329