Mitochondrial Dysfunctions in Bipolar Disorder: Effect of the Disease and Pharmacotherapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F17%3A10361785" target="_blank" >RIV/00064165:_____/17:10361785 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/17:10361785

Result on the web

<a href="http://dx.doi.org/10.2174/1871527315666161213110518" target="_blank" >http://dx.doi.org/10.2174/1871527315666161213110518</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1871527315666161213110518" target="_blank" >10.2174/1871527315666161213110518</a>

Result language

angličtina

Original language name

Mitochondrial Dysfunctions in Bipolar Disorder: Effect of the Disease and Pharmacotherapy

Original language description

Exact pathophysiological mechanisms of bipolar disorder have not been sufficiently clarified. We review the evidence of mitochondrial dysfunctions on the relation between both disease and pharmacotherapy. Mitochondria produce the most of energy-rich molecules of adenosine triphosphate (ATP), apart from energy production they are involved in other functions: regulation of free radicals, antioxidant defenses, lipid peroxidation, calcium metabolism and participate in the intrinsic pathway of apoptosis. According to increasing evidence dysfunctions of mitochondria are associated with affective disorders, a hypothesis of impaired mitochondrial functions has been proposed in bipolar disorder pathogenesis. Mitochondrial DNA mutations and/or polymorphisms, impaired phospholipid metabolism and glycolytic shift, decrease in ATP production, increased oxidative stress and changes of intracellular calcium are concerned in mood disorders and effects of mood stabilizers. Recent studies have also provided data about the positive effects of chronic treatment by mood stabilizers on mitochondrial functions.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NV15-28616A" target="_blank" >NV15-28616A: Mitochondrial dysfunctions in bipolar affective disorder</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CNS &amp; Neurological Disorders - Drug Targets

ISSN

1871-5273

e-ISSN

—

Volume of the periodical

16

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

176-186

UT code for WoS article

000399558900010

EID of the result in the Scopus database

2-s2.0-85015687273