Mitochondrial Functions in Mood Disorders

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193063" target="_blank" >RIV/00216208:11110/13:10193063 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/13:10193063
Result on the web
<a href="http://dx.doi.org/10.5772/53254" target="_blank" >http://dx.doi.org/10.5772/53254</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/53254" target="_blank" >10.5772/53254</a>

Result language
angličtina
Original language name
Mitochondrial Functions in Mood Disorders
Original language description
Biological markers of depression, predictors of the response to the drug administration and molecular targets of new antidepressants are searched on the basis of recently known hypotheses of affective disorders. We come out mostly from stimuli of neurotrophic hypothesis and mitochondrial hypothesis. According to these hypotheses, the leading role in the pathophysiology of mood disorders and therapeutic effects of antidepressants has mitochondria. Mitochondrial dysfunctions and thereby impaired neuronalmetabolism can lead to disturbances in neuronal function, plasticity and brain circuitry. Impaired functions of mitochondria contribute to a wide range of diseases; the role of mitochondria in the pathophysiology of schizophrenia, bipolar disorder, and major depressive disorder is supported by studies investigating genomic differences, changes of energy metabolism and mitochondrial changes included.
Czech name
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Czech description
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Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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