Phenotypic characterization of oral mucosa: what is normal?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F17%3A10364649" target="_blank" >RIV/00064165:_____/17:10364649 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10364649
Result on the web
<a href="http://dx.doi.org/10.1111/jop.12556" target="_blank" >http://dx.doi.org/10.1111/jop.12556</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jop.12556" target="_blank" >10.1111/jop.12556</a>

Result language
angličtina
Original language name
Phenotypic characterization of oral mucosa: what is normal?
Original language description
BACKGROUND: Knowledge of the phenotypic pattern of oral squamous epithelium is important in the histopathologic evaluation of lesions including cancer. The literature on normal epithelium is controversial as the phenotype has not been evaluated in samples from completely healthy tissue donors without a history of tobacco and alcohol exposure. METHODS: In this study, we evaluated normal upper lip fornix and gingival mucosa from carefully selected young healthy donors without a history of smoking and alcohol exposure, and keratin types 8, 10, 14, and 17, filaggrin, and Ki67 were investigated in these donors. The results were compared with profile of epithelium from leukoplakia. RESULTS: The results demonstrated that the phenotypic patterns of gingiva and upper lip fornix mucosa were different. Surprisingly, a high proportion of gingival samples exhibited keratin 8 and a suprabasal signal for keratin 14. These patterns were compared with that of human oral leukoplakia, and some phenotypic similarities were noted. CONCLUSIONS: These results demonstrated oral epithelium phenotypic plasticity based on functional requirements of the microenvironment, which can be used in diagnosis.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30106 - Anatomy and morphology (plant science to be 1.6)

Project
<a href="/en/project/NV15-28933A" target="_blank" >NV15-28933A: Tumor microenvironment of head and neck carcinoma: Prognostic significance of extracellular matrix produced by tumor-associated fibroblasts</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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