The impact of hereditary thrombophilia on the incidence of postoperative venous thromboembolism in colorectal cancer patients: aprospective cohort study: Hereditary thrombophilia and VTE in colorectal cancer surgery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10393428" target="_blank" >RIV/00064165:_____/19:10393428 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10393428 RIV/00216208:11510/19:10393428

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bAgrLE3du1" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bAgrLE3du1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10353-018-0534-0" target="_blank" >10.1007/s10353-018-0534-0</a>

Result language

angličtina

Original language name

The impact of hereditary thrombophilia on the incidence of postoperative venous thromboembolism in colorectal cancer patients: aprospective cohort study: Hereditary thrombophilia and VTE in colorectal cancer surgery

Original language description

Background: Hereditary thrombophilia may play an important role in the rate of postoperative venous thromboembolism (VTE). We focused on the impact of hereditary thrombophilia on VTE incidence in colorectal cancer surgery patients within a 1-year postoperative period. Methods: Preoperatively, identifying of colorectal cancer patients with thrombotic mutations (PTM+) and without thrombotic mutations (PTM-) was performed by screening of factor V Leiden (FVL) and prothrombin G20210A mutation. Within prophylactic period (0-28 days postoperatively), coagulation markers (platelets, fibrinogen, D-dimer) were measured and symptomatic VTE was observed. Within post-prophylactic period (2-12 months after surgery), symptomatic VTE was observed. Results: In all, 202 patients were assessed and hereditary thrombophilia was detected in 9.9% (FVL 8.4%; prothrombin G20210A mutation 1.5%). In the prophylactic period, VTE incidence in PTM+ and PTM- was 0.0% and 1.6%, respectively (p = 0.730). Levels of coagulation markers were comparable in both patient cohorts within 28 days postoperatively. In the post-prophylactic period, VTE incidence in PTM+ and PTM- was 15.0% and 5.5%, respectively (p = 0.125), and detailed incidence of deep vein thrombosis (DVT) in PTM+ and PTM- was 15.0% and 3.3%, respectively (p = 0.048). We observed significantly increased incidence of lower extremity DVT in such patients with FVL (17.6%). Conclusion: The standard regimen of extended-duration VTE prophylaxis is adequate for colorectal cancer patients with thrombotic mutations and more intensified VTE prophylaxis within the 28-day postoperative period is not justified. However, the ongoing postoperative pharmacologic prophylaxis (&gt;28 days) should be considered in patients with hereditary thrombophilia, especially with FVL.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30212 - Surgery

Project

<a href="/en/project/NT13251" target="_blank" >NT13251: The influence of thrombophilic factors to the risk of postoperative venous thromboembolism (VTE) in patients indicated for elective surgery for cancer in the abdominal cavity.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Surgery - Acta Chirurgica Austriaca

ISSN

1682-8631

e-ISSN

—

Volume of the periodical

51

Issue of the periodical within the volume

1

Country of publishing house

AT - AUSTRIA

Number of pages

8

Pages from-to

5-12

UT code for WoS article

000457151800002

EID of the result in the Scopus database

2-s2.0-85048535020