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Influence of Circulating Cell-derived Microparticles on Thrombin Generation in Thrombophilia Patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00009735" target="_blank" >RIV/61989592:15110/08:00009735 - isvavai.cz</a>

  • Alternative codes found

    RIV/00098892:_____/08:#0000082

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Influence of Circulating Cell-derived Microparticles on Thrombin Generation in Thrombophilia Patients

  • Original language description

    Thrombin generation test (TGT) was developed several years ago to mimic physiological coagulation. It can be used in many applications including assessment of thrombophilia state. We used this test for observation of influence of cell-derived microparticles, platelet (PMP) and endothelias (EMP), on thrombin generation in patients with good defined thrombophilia state such as Factor V Leiden (FVL) mutation. We evaluated thrombin generation parametres in samples with and without microparticles and determined their influence on clinical course of thrombophilia state in group of 25 carriers of heterozygous form of FVL. We found significant correlation between amount of generated thrombin and microparticles level. Patients with higher thrombin generation were more often affected by thrombotic complication.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NR9282" target="_blank" >NR9282: The significance of endothelial markers of activation in the prediction of subsequent development of preeclampsia</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Proceedings of the 20th International Congress on Thrombosis

  • ISBN

    978-88-7587-423-0

  • ISSN

  • e-ISSN

  • Number of pages

    182

  • Pages from-to

  • Publisher name

    Liapis, CD; Antonios, HN

  • Place of publication

    Ahtens, Greece

  • Event location

    20th International Congress on Thrombosis

  • Event date

    Jun 25, 2008

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article