Fluorescence assay to predict activity of the glycopeptide antibiotics

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10394481" target="_blank" >RIV/00064165:_____/19:10394481 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/19:00507230 RIV/00216208:11110/19:10394481
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-OY0-cKJtk" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-OY0-cKJtk</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41429-018-0120-5" target="_blank" >10.1038/s41429-018-0120-5</a>

Result language
angličtina
Original language name
Fluorescence assay to predict activity of the glycopeptide antibiotics
Original language description
Here, we describe a fluorescent assay developed to study competitive binding of the glycopeptide antibiotics to live bacteria cells. This assay demonstrated that the mechanism of action of the lipoglycopeptide antibiotics strongly depends on the hydrophobicity of the substitutes, with the best antibacterial activity of the glycopeptide antibiotics equally sharing properties of binding to D-Ala-D-Ala residues of the nascent peptidoglycan and to the membrane.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30102 - Immunology

Project
<a href="/en/project/NV15-28807A" target="_blank" >NV15-28807A: Mechanisms of emergence and spread of glycopeptide resistance in Staphylococcus haemolyticus</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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