Slowed articulation rate is associated with information processing speed decline in multiple sclerosis: A pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10395408" target="_blank" >RIV/00064165:_____/19:10395408 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21230/19:00332166 RIV/00216208:11110/19:10395408

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Q5_GhBEQgT" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Q5_GhBEQgT</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jocn.2019.04.018" target="_blank" >10.1016/j.jocn.2019.04.018</a>

Result language

angličtina

Original language name

Slowed articulation rate is associated with information processing speed decline in multiple sclerosis: A pilot study

Original language description

Background: Impairment of cognition and speech are common in multiple sclerosis (MS) patients, but their relationship is not well understood. Objective: To describe the relationship between articulation rate characteristics and processing speed and to investigate the potential role of objective speech analysis for the detection of cognitive decline in MS. Methods: A total of 122 patients with clinically definite MS were included in this cross-sectional pilot study. Patients underwent three speaking tasks (oral diadochokinesis, reading text and monologue) and assessment of processing speed (Symbol Digit Modalities Test [SDMT], Paced Auditory Serial Addition Test-3 s [PASAT-3]). Association between articulation rate and cognition was analyzed using linear regression analysis. We estimated the area under the receiver operating characteristics curves (AUC) to evaluate the predictive accuracy of articulation rate measures for the detection of abnormal processing speed. Results: We observed an association between articulation rate and cognitive measures (rho = 0.45-0.58; p &lt; 0.001). Faster reading speed by one word per second was associated with an 18.7 point (95% confidence interval ICI] 14.9-22.5) increase of the SDMT score and 14.7 (95% CI 8.9-20.4) point increase of PASAT-3 score (both p &lt; 0.001). AUC values of articulation rate characteristics for the identification of processing speed impairment ranged between 0.67 and 0.79. Using a cutoff of 3.10 in reading speed, we were able to identify impairment in both the SDMT and PASAT-3 with 91% sensitivity and 54% specificity. Conclusion: Slowed articulation rate is strongly associated with processing speed decline. Objective quantitative speech analysis identified patients with abnormal cognitive performance.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/GA16-03322S" target="_blank" >GA16-03322S: Investigation of pathomechanisms responsible for speech and voice disorders in multiple sclerosis using new methods of objective acoustic analysis</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Neuroscience

ISSN

0967-5868

e-ISSN

—

Volume of the periodical

65

Issue of the periodical within the volume

July

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

28-33

UT code for WoS article

000472706000006

EID of the result in the Scopus database

2-s2.0-85065065050