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Matrix Metalloproteinases in Renal Diseases: A Critical Appraisal

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10395860" target="_blank" >RIV/00064165:_____/19:10395860 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/19:10395860

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7USwxLyAmV" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7USwxLyAmV</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1159/000499876" target="_blank" >10.1159/000499876</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Matrix Metalloproteinases in Renal Diseases: A Critical Appraisal

  • Original language description

    Matrix metalloproteinases (MMPs) are endopeptidases within the metzincin protein family that not only cleave extracellular matrix (ECM) components, but also process the non-ECM molecules, including various growth factors and their binding proteins. MMPs participate in cell to ECM interactions, and MMPs are known to be involved in cell proliferation mechanisms and most probably apoptosis. These proteinases are grouped into six classes: collagenases, gelatinases, stromelysins, matrilysins, membrane type MMPs, and other MMPs. Various mechanisms regulate the activity of MMPs, inhibition by tissue inhibitors of metalloproteinases being the most important. In the kidney, intrinsic glomerular cells and tubular epithelial cells synthesize several MMPs. The measurement of circulating MMPs can provide valuable information in patients with kidney diseases. They play an important role in many renal diseases, both acute and chronic. This review attempts to summarize the current knowledge of MMPs in the kidney and discusses recent data from patient and animal studies with reference to specific diseases. A better understanding of the MMPs&apos; role in renal remodeling may open the way to new interventions favoring deleterious renal changes in a number of kidney diseases.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30217 - Urology and nephrology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Kidney &amp; Blood Pressure Research

  • ISSN

    1420-4096

  • e-ISSN

  • Volume of the periodical

    44

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    33

  • Pages from-to

    298-330

  • UT code for WoS article

    000473611100002

  • EID of the result in the Scopus database

    2-s2.0-85067470905