Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10439365" target="_blank" >RIV/00216208:11110/21:10439365 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/21:10439365
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=EkXV4FeZVQ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=EkXV4FeZVQ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/bs.acc.2021.02.003" target="_blank" >10.1016/bs.acc.2021.02.003</a>
Alternative languages
Result language
angličtina
Original language name
Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease
Original language description
Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell surface components and regulate multiple cellular processes, cell to cell interactions, cell proliferation, and cell signaling pathways. MMPs function in close interaction with the endogenous tissue inhibitors of matrix metalloproteinases (TIMPs), both of which regulate cell turnover, modulate various growth factors, and participate in the progression of tissue fibrosis and apoptosis. The multiple roles of MMPs and TIMPs are continuously elucidated in kidney development and repair, as well as in a number of kidney diseases. This chapter focuses on the current findings of the significance of MMPs and TIMPs in a wide range of kidney diseases, whether they result from kidney tissue changes, hemodynamic alterations, tubular epithelial cell apoptosis, inflammation, or fibrosis. In addition, the potential use of these endopeptidases as biomarkers of renal dysfunction and as targets for therapeutic interventions to attenuate kidney disease are also explored in this review.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advances in Clinical Chemistry
ISSN
0065-2423
e-ISSN
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Volume of the periodical
105
Issue of the periodical within the volume
March
Country of publishing house
US - UNITED STATES
Number of pages
72
Pages from-to
141-212
UT code for WoS article
000748730100005
EID of the result in the Scopus database
2-s2.0-85102285480