A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10396381" target="_blank" >RIV/00064165:_____/19:10396381 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10396381
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=cbP2TZNJ6x" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=cbP2TZNJ6x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-019-09773-y" target="_blank" >10.1038/s41467-019-09773-y</a>
Alternative languages
Result language
angličtina
Original language name
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis
Original language description
Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations has proven extremely difficult. Even determining which cell types and which particular gene(s) are relevant continues to be a challenge. Here, we conduct a cell-specific pathway analysis of the latest GWAS in multiple sclerosis (MS), which had analyzed a total of 47,351 cases and 68,284 healthy controls and found more than 200 non-MHC genome-wide associations. Our analysis identifies pan immune cell as well as cell-specific susceptibility genes in T cells, B cells and monocytes. Finally, genotype-level data from 2,370 patients and 412 controls is used to compute intraindividual and cell-specific susceptibility pathways that offer a biological interpretation of the individual genetic risk to MS. This approach could be adopted in any other complex trait for which genome-wide data is available.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications [online]
ISSN
2041-1723
e-ISSN
—
Volume of the periodical
10
Issue of the periodical within the volume
May
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
2236
UT code for WoS article
000468275100001
EID of the result in the Scopus database
2-s2.0-85066046672