Letter to the editor: hypoglycemia and treatment with opioids

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10398557" target="_blank" >RIV/00064165:_____/19:10398557 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10398557 RIV/00216208:11130/19:10398557 RIV/00064203:_____/19:10398557
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NmWQz3kLBZ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NmWQz3kLBZ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14740338.2019.1673363" target="_blank" >10.1080/14740338.2019.1673363</a>

Result language
angličtina
Original language name
Letter to the editor: hypoglycemia and treatment with opioids
Original language description
We read with interest the review article by Chrétien et al, "Comparative study of hypoglycemia induced by opioids. Is it a class effect?" published online in this journal. The authors performed a disproportionality analysis in the WHO global individual case safety report database and in the French PharmacoVigilance DataBase (FPVD) with nine opioids (codeine, fentanyl, hydromorphone, methadone, morphine, oxycodone, tramadol, buprenorphine, and nalbuphine) looking for any indications of hypoglycemia. The authors concluded that this work highlighted a significant association between all opioids and hypoglycemia, thereby indicating that opioid-induced hypoglycemia is probably a class effect. Women and diabetics seem to be more at risk for developing opioid-induced hypoglycemia. We think a detailed analysis of hypoglycemic events related not only to tramadol in nondiabetic subjects would be a much more valuable support to the authors' conclusions (we presume that the remaining 48 cases are related to non-diabetic patients). It would be interesting to know the hypoglycemia definition used in those cases, the value of hypoglycemia and concomitant diseases, especially those which could contribute to hypoglycemia like renal and liver diseases, if such data are available.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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