Actual body weight-based vancomycin dosing in neonates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10399136" target="_blank" >RIV/00064165:_____/19:10399136 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10399136
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WCQOGmg5xG" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WCQOGmg5xG</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/1120009X.2019.1599574" target="_blank" >10.1080/1120009X.2019.1599574</a>
Alternative languages
Result language
angličtina
Original language name
Actual body weight-based vancomycin dosing in neonates
Original language description
This study aimed to explore vancomycin pharmacokinetics and its covariates in critically ill neonates and to propose an easy applicable dosing nomogram for initial treatment. Individual vancomycin pharmacokinetic parameters were calculated based on therapeutic drug monitoring data using a one-compartmental model. A linear regression model was used for examination of covariates. The mean (SD) volume of distribution (Vd) and clearance (CL) for vancomycin were 0.73 (0.31) L/kg and 0.052 (0.020) L/h/kg, respectively. Vd was related to actual body weight (ABW), gestational and postmenstrual age. CL was also associated with ABW, gestational, postmenstrual age and also creatinine clearance. ABW was the strongest predictor for vancomycin pharmacokinetics and consequently dosing. Loading dose (mg) of 11.81 x ABW (kg) + 7.86 and maintenance dose (mg/day) of 40.92 x ABW (kg) -22.18 most closely approximated pharmacokinetic target. Vancomycin pharmacokinetics was mainly influenced by ABW in neonates and a practical ABW-based dosing algorithm was developed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Chemotherapy
ISSN
1120-009X
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
6
Country of publishing house
IT - ITALY
Number of pages
6
Pages from-to
307-312
UT code for WoS article
000466671400001
EID of the result in the Scopus database
2-s2.0-85064506057