Nomogram based on actual body weight for estimation of vancomycin maintenance dose in infants

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10399176" target="_blank" >RIV/00064165:_____/19:10399176 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10399176

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=peCQrN4Qwd" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=peCQrN4Qwd</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/23744235.2018.1541250" target="_blank" >10.1080/23744235.2018.1541250</a>

Result language

angličtina

Original language name

Nomogram based on actual body weight for estimation of vancomycin maintenance dose in infants

Original language description

Background: Vancomycin is the first-choice antibiotic for infants with -lactam-resistant gram-positive bacterial infection. Despite long experience of prescribing of this drug optimal dosing is still challenging. This study aimed at investigating variables predicting vancomycin clearance in order to propose optimal maintenance dosing in infants treated for suspected or culture-proven sepsis.Methods: Vancomycin pharmacokinetics was calculated in a one-compartmental model based on serum concentrations. A linear regression model was used to explore relationships between vancomycin clearance and expected covariates.Results: Twenty-two patients were enrolled into the study. Median (IQR) postnatal age was 157 (112-238) days. The median (IQR) volume of distribution and clearance for vancomycin were 0.50 (0.39-0.94) L/kg and 0.112 (0.095-0.133) L/h/kg, respectively. Vancomycin clearance was associated with actual body weight, height, body surface area, gestational age, postnatal age, postmenstrual age and estimate glomerular filtration rate. Actual body weight was the best predictive variable for vancomycin clearance. Daily maintenance dose (mg) calculated as 76.28xactual body weight (kg) - 41.57 most closely approximated optimal dosing based on individual pharmacokinetics. This relationship was used to construct a dosing nomogram.Conclusions: We developed an easy-to-use dosing nomogram for maintaining a vancomycin average steady-state concentration of 22.5mg/L based on actual body weight.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Infectious Diseases

ISSN

2374-4235

e-ISSN

—

Volume of the periodical

51

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

334-339

UT code for WoS article

000466814500002

EID of the result in the Scopus database

2-s2.0-85063963038