Factors Responsible for Cerebral Hypoxia in Hemodialysis Population
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10399145" target="_blank" >RIV/00064165:_____/19:10399145 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10399145
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=U7DSmRuRp~" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=U7DSmRuRp~</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934064" target="_blank" >10.33549/physiolres.934064</a>
Alternative languages
Result language
angličtina
Original language name
Factors Responsible for Cerebral Hypoxia in Hemodialysis Population
Original language description
Brain tissue oxygenation (rSO(2)) measured by near-infrared spectroscopy (NIRS) is lower in hemodialysis patients than in the healthy population and is associated with cognitive dysfunction. The involved mechanisms are not known. We conducted this study to identify the factors that influence the rSO(2) values in end-stage renal disease (ESRD) patients and to describe rSO(2) changes during hemodialysis. We included a cohort of ESRD patients hemodialyzed in our institution. We recorded rSO(2) using INVOS 5100C oximetry system (Medtronic, Essex, U.K.) and analyzed changes in basic laboratory values and hemodynamic fluctuations. Baseline rSO(2) was lower in patients with heart failure (45.2 +/- 8.3 % vs. 54.1 +/- 7.8 %, p=0.006) and was significantly linked to higher red cell distribution width (RDW) (r=-0.53, p<0.001) and higher BNP level (r=-0.45, p=0.01). The rSO(2) value decreased in first 15 min of hemodialysis, this decrease correlated with drop in white blood count during the same period (r=0.43, p=0.02 in 10 min, r=0.43, p=0.02 in 20 min). Lower rSO(2) values in patients with heart failure and higher RDW suggest that hemodynamic instability combined with vascular changes probably leads to worse cerebral oxygenation in these patients. Decrease of rSO(2) in 15th minute of hemodialysis accompanied with a significant drop in leukocyte count could be explained by complement activation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
<a href="/en/project/NV17-31796A" target="_blank" >NV17-31796A: Tissue hypoxia in patients with chronic kidney disease – metabolic and hemodynamic associations</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
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Volume of the periodical
68
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
651-658
UT code for WoS article
000483374200013
EID of the result in the Scopus database
2-s2.0-85071711603