Therapeutic drug monitoring of antibiotic agents: evaluation of predictive performance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10399834" target="_blank" >RIV/00064165:_____/19:10399834 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10399834
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ms3~k1GCBU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ms3~k1GCBU</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/ejhpharm-2017-001396" target="_blank" >10.1136/ejhpharm-2017-001396</a>
Alternative languages
Result language
angličtina
Original language name
Therapeutic drug monitoring of antibiotic agents: evaluation of predictive performance
Original language description
Background: The precision of the population pharmacokinetic model used in therapeutic drug monitoring (TDM) is essential for successful dosage optimisation. Objective: To evaluate the predictive performance of pharmacokinetic models used in our hospital and to evaluate the possible impact of demographic characteristics or renal function on TDM accuracy. Methods: We compared a posteriori an adjusted concentration-time curve profile based on the first measured drug concentration with the second measured drug concentration. Linear regression models were used to compare predicted and observed drug serum concentrations, and to evaluate potential relationships between predictive performance and patients' demographic/clinical features. Predictive performance of TDM was expressed using accuracy, precision, sensitivity and specificity. Results: One hundred and fifty-two patients were enrolled in the study. All pharmacokinetic models showed good predictive performance expressed by the coefficient of determination (r2) of 0.5642, 0.7263, 0.9001 and 0.9454 for continuous vancomycin, intermittent vancomycin, amikacin and gentamicin, respectively. Accuracy was 93.3%, 91.2%, 113.9% and 130.9% for continuous vancomycin, intermittent vancomycin, amikacin and gentamicin, respectively. Demographic characteristics or renal functions had no substantial impact on the accuracy of TDM. Conclusion: We found the predictive performance of both aminoglycosides and vancomycin pharmacokinetic models to be satisfactory.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Hospital Pharmacy: Science and Practice
ISSN
2047-9956
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
85-88
UT code for WoS article
000471820200006
EID of the result in the Scopus database
2-s2.0-85049071754