Fractional Exhaled Nitric Oxide and Nanomaterial Exposure in Workplaces
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F20%3A10419587" target="_blank" >RIV/00064165:_____/20:10419587 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/20:10419587
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8dH1ca-a.3" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8dH1ca-a.3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/0929867327666200320154545" target="_blank" >10.2174/0929867327666200320154545</a>
Alternative languages
Result language
angličtina
Original language name
Fractional Exhaled Nitric Oxide and Nanomaterial Exposure in Workplaces
Original language description
Background: The widespread application of engineered nanomaterials (ENMs) and the increasing likelihood of general and occupational exposure raised concerns on their possible human health impact. ENMs, in fact, may induce alterations in different organ systems, and particularly in the respiratory tract. This makes it important to identify possible biomarkers of early lung effect in exposed workers. In this regard, the possibility to use the fractional exhaled levels of nitric oxide (FENO) in biological monitoring has attracted considerable interest. Objective: To comprehensively assess the role of FENO as a possible biomarker of lung effect in ENM exposed workers. Methods: A systematic search was performed on Pubmed, Scopus, and ISI Web of Knowledge databases according to the PRISMA guidelines. Results: Seven studies investigated FENO in workers exposed to different kinds of metal- (i.e. silver and gold), metal oxide- (titanium and silica dioxide), and carbon-based ENMs (carbon nanotubes). In general, no significant alterations were detected between exposed workers and controls. Conclusion: Definite conclusion on the function of FENO in occupational biological monitoring cannot be extrapolated due to the limited number of available studies and the small size of investigated populations. Additionally, the lack of environmental monitoring data and the fragmented knowledge on ENM modes of action prevent to establish dose-response relationships. Future research appears necessary to deeply define the possibility to employ FENO as an early biomarker of lung effects taking in consideration possible occupational exposure issues, i.e. differently characterized ENMs and work tasks, as well as individual influencing factors, i.e. smoking and atopy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
<a href="/en/project/GA18-02079S" target="_blank" >GA18-02079S: The effect of nanoparticles exposure on DNA alterations in a human population</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Medicinal Chemistry
ISSN
0929-8673
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
42
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
13
Pages from-to
7200-7212
UT code for WoS article
000599809500007
EID of the result in the Scopus database
2-s2.0-85090626552