Males-females differences in the spectrum of chromosomal aberrations in the group of nanocomposites production workers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F20%3A10425184" target="_blank" >RIV/00064165:_____/20:10425184 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/20:10425184 RIV/46747885:24210/20:00009498 RIV/68378041:_____/20:00560220

Result on the web

<a href="https://doi.org/10.37904/nanocon.2019.8589" target="_blank" >https://doi.org/10.37904/nanocon.2019.8589</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/nanocon.2019.8589" target="_blank" >10.37904/nanocon.2019.8589</a>

Result language

angličtina

Original language name

Males-females differences in the spectrum of chromosomal aberrations in the group of nanocomposites production workers

Original language description

An increase in the use of nanomaterials (NM) has been witnessed in many areas of human life. Therefore, assessment of genotoxicity of NM and nanoparticles (NP) is one of the main objectives of genetic toxicology. Despite this fact, human cytogenetic studies following the exposure to NP are still rare. Moreover, no relevant information on possible differences in sensitivity to NP related to gender is available. In this study we periodically (in September 2016, 2017 and 2018; pre-shift and post-shift each year) analyzed a group of workers (both genders), working long time in nanocomposites research, and matched controls. Aerosol exposure monitoring of particulate matter including nano-sized fractions was carried out during working shift. Micronucleus assay using Human Pan Centromeric probes, was applied to distinguish, besides the frequency of total MN in binucleated cells (BNC), also other types of chromosomal damage (losses and breaks). Moreover, whole-chromosome painting (WCP) for autosome #1 and both gonosomes (X and Y) were applied in third sampling period (2018) with the aim to identify the particular structural and numerical chromosomal aberrations. Obtained results showed: (i) differences in the risk of exposure to NP related to individual working processes (welding, smelting and machining); (ii) differences in chemical composition of nano-fraction; (iii) no effect of chronic exposure of NP (total MN) opposite to significant effect of acute exposure; (iv) gender-related DNA damage differences (females seem to be more sensitive to chromosomal losses). Additional data from WCP suggested increased frequency of numerical aberrations in gonosomes.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

—

OECD FORD branch

30304 - Public and environmental health

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

NANOCON 2019 : conference proceedings

ISBN

978-80-87294-95-6

ISSN

2694-930X

e-ISSN

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Number of pages

6

Pages from-to

502-507

Publisher name

Tanger

Place of publication

Brno

Event location

Brno

Event date

Oct 16, 2019

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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