The stiffness variability of a silk fibroin scaffold during bone cell proliferation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10442530" target="_blank" >RIV/00064165:_____/22:10442530 - isvavai.cz</a>
Alternative codes found
RIV/46747885:24210/22:00009390 RIV/46747885:24220/22:00009390 RIV/46747885:24410/22:00009390 RIV/46747885:24620/22:00009390 RIV/00216208:11110/22:10442530
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dXWz4l_YZh" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dXWz4l_YZh</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/09544119211070345" target="_blank" >10.1177/09544119211070345</a>
Alternative languages
Result language
angličtina
Original language name
The stiffness variability of a silk fibroin scaffold during bone cell proliferation
Original language description
Complex assessment of gradual changes in scaffold morphology and stiffness is an essential step in bone filler development. Current approach, however, does not reflect long term cell proliferation effect as the mechanical tests are usually conducted on pristine materials without cells or cell influence on material stiffness is evaluated after one time period only. Here, biocompatible silk fibroin (SF) porous scaffolds envisioned for bone defect filling were prepared by dissolving of fibroin fibers, followed by dialysis, freeze-drying and final stabilization. Particular attention was devoted to the influence of bone cell proliferation up to 2 months on the stiffness of the material. The morphology of the material was studied in terms of its inner structure and the overall changes in the surface characteristics due to proliferation of MG 63 bone cell line. The SF scaffold stiffness significantly increased during first month followed by its decline during second month due to bone cell seeding. After 2 months, the SF scaffold was completely colonized, which resulted in a gradual decay of its structure. The length of degradation due to bone cell proliferation and mechanical behavior corresponded to the requirements set for reasonable filler material indicating that porous SF scaffolds comprise a promising biomaterial for bone regeneration.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30106 - Anatomy and morphology (plant science to be 1.6)
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
ISSN
0954-4119
e-ISSN
2041-3033
Volume of the periodical
236
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
539-546
UT code for WoS article
000753529300001
EID of the result in the Scopus database
2-s2.0-85124912635