The stiffness variability of a silk fibroin scaffold during bone cell proliferation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24210%2F22%3A00009390" target="_blank" >RIV/46747885:24210/22:00009390 - isvavai.cz</a>

Alternative codes found

RIV/46747885:24220/22:00009390 RIV/46747885:24410/22:00009390 RIV/46747885:24620/22:00009390 RIV/00064165:_____/22:10442530 RIV/00216208:11110/22:10442530

Result on the web

<a href="https://journals.sagepub.com/doi/pdf/10.1177/09544119211070345" target="_blank" >https://journals.sagepub.com/doi/pdf/10.1177/09544119211070345</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/09544119211070345" target="_blank" >10.1177/09544119211070345</a>

Result language

angličtina

Original language name

The stiffness variability of a silk fibroin scaffold during bone cell proliferation

Original language description

Complex assessment of gradual changes in scaffold morphology and stiffness is an essential step in bone filler development. Current approach, however, does not reflect long term cell proliferation effect as the mechanical tests are usually conducted on pristine materials without cells or cell influence on material stiffness is evaluated after one time period only. Here, biocompatible silk fibroin (SF) porous scaffolds envisioned for bone defect filling were prepared by dissolving of fibroin fibers, followed by dialysis, freeze-drying and final stabilization. Particular attention was devoted to the influence of bone cell proliferation up to 2 months on the stiffness of the material. The morphology of the material was studied in terms of its inner structure and the overall changes in the surface characteristics due to proliferation of MG 63 bone cell line. The SF scaffold stiffness significantly increased during first month followed by its decline during second month due to bone cell seeding. After 2 months, the SF scaffold was completely colonized, which resulted in a gradual decay of its structure. The length of degradation due to bone cell proliferation and mechanical behavior corresponded to the requirements set for reasonable filler material indicating that porous SF scaffolds comprise a promising biomaterial for bone regeneration.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Proceedings of the Institution of Mechanical Engineers Part H-Journal of engineering in medicine

ISSN

0954-4119

e-ISSN

—

Volume of the periodical

236

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

539-546

UT code for WoS article

000753529300001

EID of the result in the Scopus database

2-s2.0-85124912635