Pregnancy-induced brain magnetic resonance imaging changes in women with multiple sclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10443236" target="_blank" >RIV/00064165:_____/22:10443236 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/22:10443236

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=UKEvqAwIEa" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=UKEvqAwIEa</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ene.15245" target="_blank" >10.1111/ene.15245</a>

Result language

angličtina

Original language name

Pregnancy-induced brain magnetic resonance imaging changes in women with multiple sclerosis

Original language description

Background and purpose: The effect of pregnancy on brain changes and radiological disease activity in women with multiple sclerosis (MS) is not well understood. This study was undertaken to describe the dynamics of lesion activity and brain volume changes during the pregnancy and postpartum periods. Methods: This observational study of 62 women with relapsing-remitting MS included magnetic resonance imaging (221 scans) as well as clinical visits at baseline (&lt;24 and &gt;6 months before pregnancy), prepregnancy (&lt;6 months before pregnancy), postpartum (&lt;3 months after delivery), and follow-up (&gt;12 and &lt;24 months after delivery) periods. Results: The majority of women had a mild disability and a short disease duration (median = 5.5 years). Eighteen (29.0%) women had a relapse during the year preceding pregnancy onset, nine (14.5%) during pregnancy, and 20 (32.3%) in the year following delivery. Disability status remained unchanged during follow-up. Women in the postpartum period (n = 62) had higher T2 lesion volume (median = 1.18 ml vs. 0.94 ml), greater annualized T2 lesion volume increase (0.23 ml vs. 0.0 ml), lower brain parenchymal fraction (85.6% vs. 86.4%), and greater annualized brain volume loss (-1.74% vs. -0.16%) compared with the prepregnancy period (all p &lt; 0.001). At 12-24 months after delivery, women (n = 41) had higher T2 lesion volume (1.16 ml vs. 1.0 ml) and lower brain parenchymal fraction (86.0% vs. 86.5%) compared to the prepregnancy period (both p &lt; 0.001). Conclusions: The postpartum period was associated with an increase in T2 lesion volume and accelerated brain volume loss in a considerable proportion of women. This should be considered in treatment decision-making and designing clinical trials.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NV18-08-00062" target="_blank" >NV18-08-00062: Quantitative multiparametric MRI for longitudinal monitoring of multiple sclerosis: correlation with clinical status and biochemical markers</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Neurology

ISSN

1351-5101

e-ISSN

1468-1331

Volume of the periodical

29

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1446-1456

UT code for WoS article

000745867800001

EID of the result in the Scopus database

2-s2.0-85123502123