Early predictors of non-response to interferon in multiple sclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11531" target="_blank" >RIV/00216208:11110/12:11531 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/12:11531

Result on the web

<a href="http://dx.doi.org/10.1111/j.1600-0404.2012.01662.x" target="_blank" >http://dx.doi.org/10.1111/j.1600-0404.2012.01662.x</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Early predictors of non-response to interferon in multiple sclerosis

Original language description

Objective - To identify early clinical and MRI predictors of non-response to interferon (IFN) treatment in multiple sclerosis (MS). Methods - In 172 patients with relapsing-remitting MS treated with IFN beta, we evaluated prediction of future treatment non-response. Candidate predictors comprised disability and its sustained progression, relapse score (combining frequency and severity of relapses), brain volume change, brain parenchymal fraction, number of new T2 lesions, and T2 and T1 lesion volume within the initial year of treatment. Treatment non-response was evaluated as confirmed disability progression or overall average annual relapse score exceeding 1 over the following 5 years. Logistic regression model was adjusted for patient age, gender, disease duration and changes in treatment. Results - Ninety patients (52%) reached the status of IFN non-responders in years 2-6. Patients with >= 1 new T2 lesion and relapse score >= 2 (odds ratio >= 5.7) or those with >= 3 new T2 lesions

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Neurologica Scandinavica

ISSN

0001-6314

e-ISSN

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Volume of the periodical

126

Issue of the periodical within the volume

6

Country of publishing house

DK - DENMARK

Number of pages

8

Pages from-to

390-397

UT code for WoS article

000310545400005

EID of the result in the Scopus database

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