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Thyroid nodules and thyroid cancer in women with positive thyroid screening in pregnancy: a double-centric, retrospective, cohort study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10445124" target="_blank" >RIV/00064165:_____/22:10445124 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/22:10445124 RIV/00216208:11150/22:10445124 RIV/00179906:_____/22:10445124

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=IxfrtItbQ9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=IxfrtItbQ9</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1530/ETJ-21-0011" target="_blank" >10.1530/ETJ-21-0011</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Thyroid nodules and thyroid cancer in women with positive thyroid screening in pregnancy: a double-centric, retrospective, cohort study

  • Original language description

    Objective: Thyroid nodules are a common finding in the general population. The primary aim of the study was to determine the prevalence of thyroid nodules and cancer found by ultrasound (US) in women who underwent screening for thyroid dysfunction during pregnancy. Design: A double-centric, retrospective, cohort study. Patients and methods: We searched through medical records, including thyroid ultrasonography, of pregnant women who were positively screened for thyroid disorders (using thyroid-stimulating hormone and thyroid antibodies) from an unselected population (&apos;universal screening group&apos;, n = 690) and of women who underwent the testing based on the presence of clinical risk factors defined by American Thyroid Association (&apos;case-finding group&apos;, n = 249). Results: Prevalence of benign and malignant thyroid nodules was lower in the &apos;universal screening group&apos; than in the &apos;case-finding group&apos; (9.9% vs 17.7%, P=0.002, and 0.9% vs 7.2%, P &lt; 0.001, respectively). Consistently, the thyroid cancer rate was lower among the nodules in the &apos;universal screening group&apos; than in the &apos;case-finding group&apos; (8.1% vs 29.0%, P=0.003). Ultrasound EU-TIRADS (European Thyroid Imaging and Reporting Data System) category &gt;= 4 had a 95.8% sensitivity for thyroid cancer. In palpable nodules, the prevalence of cancer was significantly higher than in the non-palpable ones (44.0% vs 2.2%, P &lt; 0.001). In a multivariate regression analysis, thyroid nodules were associated with a history of infertility and parity. Conclusions: Compared to the data from cancer registries, universal screening allowed detecting thyroid cancer in pregnancy three to five times more frequently, but the cancer rate among nodules (8.1%) did not differ from the common population. US had very good sensitivity for thyroid cancer in pregnancy.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Thyroid Journal

  • ISSN

    2235-0640

  • e-ISSN

    2235-0802

  • Volume of the periodical

    11

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    9

  • Pages from-to

    e210011

  • UT code for WoS article

    000808463200011

  • EID of the result in the Scopus database