Relation of prediabetes and type 2 diabetes mellitus to thyroid cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920433" target="_blank" >RIV/00216208:11120/20:43920433 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/20:N0000006 RIV/00064173:_____/20:N0000044 RIV/00023001:_____/20:00080012
Result on the web
<a href="https://doi.org/10.1530/EC-20-0180" target="_blank" >https://doi.org/10.1530/EC-20-0180</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1530/EC-20-0180" target="_blank" >10.1530/EC-20-0180</a>
Alternative languages
Result language
angličtina
Original language name
Relation of prediabetes and type 2 diabetes mellitus to thyroid cancer
Original language description
Objective: Patients with type 2 diabetes (T2DM) generally experience a higher incidence of cancer. However, the association between T2DM and thyroid cancer is inconclusive. Methods: Case-control prospective study, where 722 patients were screened for T2DM and prediabetes (PDM) and underwent thyroid ultrasound and biochemical tests. The patients were assigned to groups of PDM (n = 55), T2DM (n = 79) or a non-diabetes group (NDM) (n = 588). Fine-needle aspiration biopsy was carried out in 263 patients. Histological examinations were done for 109 patients after surgery, with findings of 52 benign (BS) and 57 malignant tumors (MS). Results: Thirty-three percent of patients with T2DM and especially PDM were newly diagnosed by our screening: 6.5% with T2DM and 72% with PDM, re spectively. The percentage of thyroid cancers did not significantly differ between the groups (chi(2) test = 0.461; P = 0.794). Relevant positive thyroid predictors for T2DM (t-statistic = 25.87; P < 0.01) and PDM (21.69; P < 0.01) contrary to NDM (-26.9; P < 0.01) were thyroid volume (4.79; P < 0.01), thyroid nodule volume (3.25; P < 0.01) and multinodular thyroid gland (4.83; P < 0.01), while negative relevant predictors included the occurrence of autoimmune thyroid disease (AITD) (-2.01; P < 0.05). Conclusion: In general, we did not observe an increased risk for thyroid cancer in the diabetic and prediabetic groups in comparison to controls, in spite of well-established increased risk for other malignancies. Structural and benign changes such as larger and multinodular thyroid glands, in comparison to autoimmune thyroid disease, are present more often in diabetics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Endocrine Connections
ISSN
2049-3614
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
607-616
UT code for WoS article
000560003100006
EID of the result in the Scopus database
2-s2.0-85090740944