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Relation of prediabetes and type 2 diabetes mellitus to thyroid cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920433" target="_blank" >RIV/00216208:11120/20:43920433 - isvavai.cz</a>

  • Alternative codes found

    RIV/00023761:_____/20:N0000006 RIV/00064173:_____/20:N0000044 RIV/00023001:_____/20:00080012

  • Result on the web

    <a href="https://doi.org/10.1530/EC-20-0180" target="_blank" >https://doi.org/10.1530/EC-20-0180</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1530/EC-20-0180" target="_blank" >10.1530/EC-20-0180</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Relation of prediabetes and type 2 diabetes mellitus to thyroid cancer

  • Original language description

    Objective: Patients with type 2 diabetes (T2DM) generally experience a higher incidence of cancer. However, the association between T2DM and thyroid cancer is inconclusive. Methods: Case-control prospective study, where 722 patients were screened for T2DM and prediabetes (PDM) and underwent thyroid ultrasound and biochemical tests. The patients were assigned to groups of PDM (n = 55), T2DM (n = 79) or a non-diabetes group (NDM) (n = 588). Fine-needle aspiration biopsy was carried out in 263 patients. Histological examinations were done for 109 patients after surgery, with findings of 52 benign (BS) and 57 malignant tumors (MS). Results: Thirty-three percent of patients with T2DM and especially PDM were newly diagnosed by our screening: 6.5% with T2DM and 72% with PDM, re spectively. The percentage of thyroid cancers did not significantly differ between the groups (chi(2) test = 0.461; P = 0.794). Relevant positive thyroid predictors for T2DM (t-statistic = 25.87; P &lt; 0.01) and PDM (21.69; P &lt; 0.01) contrary to NDM (-26.9; P &lt; 0.01) were thyroid volume (4.79; P &lt; 0.01), thyroid nodule volume (3.25; P &lt; 0.01) and multinodular thyroid gland (4.83; P &lt; 0.01), while negative relevant predictors included the occurrence of autoimmune thyroid disease (AITD) (-2.01; P &lt; 0.05). Conclusion: In general, we did not observe an increased risk for thyroid cancer in the diabetic and prediabetic groups in comparison to controls, in spite of well-established increased risk for other malignancies. Structural and benign changes such as larger and multinodular thyroid glands, in comparison to autoimmune thyroid disease, are present more often in diabetics.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Endocrine Connections

  • ISSN

    2049-3614

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    10

  • Pages from-to

    607-616

  • UT code for WoS article

    000560003100006

  • EID of the result in the Scopus database

    2-s2.0-85090740944