Metal hypersensitivity and pro-inflammatory cytokine production in patients with failed orthopedic implants: A case-control study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10450837" target="_blank" >RIV/00064165:_____/22:10450837 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10450837
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=g7laEKZOZc" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=g7laEKZOZc</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clim.2022.109152" target="_blank" >10.1016/j.clim.2022.109152</a>

Result language
angličtina
Original language name
Metal hypersensitivity and pro-inflammatory cytokine production in patients with failed orthopedic implants: A case-control study
Original language description
Orthopedic implants heal well without complications in most patients but fail for unclear reasons in some in-dividuals. This study determined the relevance of metal hypersensitivity in patients with failed orthopedic im-plants and those requiring orthopedic implant surgery. The study included 35 patients with failed orthopedic implants and 15 subjects scheduled for orthopedic implant surgery. The production of selected pro-inflammatory cytokines was measured in patients with failed orthopedic implants. Metal hypersensitivity was measured in all subjects using the MELISA (R) test. Of common metals in orthopedic alloys, the patients with failed orthopedic implants responded most frequently to nickel, chromium, titanium, iron, and molybdenum. Hypersensitivity to metals found in implants was measured in 40% of patients with failed implants. The study also showed that titanium exposure in patients with titanium hypersensitivity might lead to implant failure. Metal hypersensitivity testing should be offered to patients before surgery to minimize the risk of implant failure.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30208 - Dentistry, oral surgery and medicine

Project
<a href="/en/project/NV19-08-00070" target="_blank" >NV19-08-00070: Use of lymphocytes of hypersensitive patients for preclinical testing of advanced titanium-based materials modified by ion beam</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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