Type IV titanium hypersensitivity: rare, or rarely detected?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F23%3AE0110286" target="_blank" >RIV/00843989:_____/23:E0110286 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/23:A2402NNL

Result on the web

<a href="https://www.achot.cz/pdfs/ach/2023/02/01.pdf" target="_blank" >https://www.achot.cz/pdfs/ach/2023/02/01.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Type IV titanium hypersensitivity: rare, or rarely detected?

Original language description

The presented review aims to summarize the current knowledge of hypersensitivity to titanium - a material widely used in medical applications thanks to its exceptional chemical stability, resistance to corrosion, low specific weight and high strength. The hypersensitivity to metals is usually caused by the Type IV immunopathological reaction. Case reports on allergic reactions to titanium are rare but the actual occurrence can be expected to be much higher, especially due to its problematic detection. Although cutaneous patch tests are widely accepted and used for the diagnosis of hypersensitivity of numerous metals (e.g. Ni), it is notoriously unreliable in case of allergies to titanium, which may be associated with the low percutaneous transport of titanium and its salts. The Lymphocyte Transformation Test has superior sensitivity but it remains mostly unknown among clinicians and there are not many laboratories capable of performing it. This review presents numerous case reports indicating, in combination with the above-mentioned facts, that hypersensitivity to titanium should be considered as a possible cause also in non-specific problems associated with titanium implant failure. Key words: titanium, allergy, patch test, lymphocyte transformation test.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project

<a href="/en/project/EF17_049%2F0008441" target="_blank" >EF17_049/0008441: Innovative therapeutic methods of musculoskeletal system in accident surgery</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta chirurgiae orthopaedicae et traumatologiae čechoslovaca

ISSN

0001-5415

e-ISSN

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Volume of the periodical

90

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

85-91

UT code for WoS article

000995079600001

EID of the result in the Scopus database

2-s2.0-85158136061