Disorders of Sulfur Amino Acid and Hydrogen Sulfide Metabolism
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10452306" target="_blank" >RIV/00064165:_____/22:10452306 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10452306
Result on the web
<a href="http://dx.doi.org/10.1007/978-3-030-67727-5_22" target="_blank" >http://dx.doi.org/10.1007/978-3-030-67727-5_22</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-030-67727-5_22" target="_blank" >10.1007/978-3-030-67727-5_22</a>
Alternative languages
Result language
angličtina
Original language name
Disorders of Sulfur Amino Acid and Hydrogen Sulfide Metabolism
Original language description
The conversion of methionine to inorganic sulfate involves the formation of homocysteine encompassing transmethylation followed by transsulfuration. Several inherited enzyme deficiencies within this pathway have been described. Those causing hypermethioninemia may be confused with the many known secondary causes of increased methionine demanding diagnostic expediency. Most of the disorders have been described in small numbers of patients so that the full clinical spectrum of these is not known. Exceptions are methionine adenosyltransferase (MAT) I/III deficiency and cystathionine ß-synthase deficiency which causes classical homocystinuria, characterized primarily by an increased risk of thrombosis and embolism, lens dislocation, and other connective tissue involvement and cognitive impairment. While methionine adenosyltransferase I/III deficiency is only symptomatic in some patients causing different neurological problems and glycine N-methyltransferase deficiency affects liver function, other diseases causing hypermethioninemias may be associated with a multisystem disease of varying severity and progression. MAT II deficiency can be associated with thoracic aortic aneurysms in some heterozygotes for MAT2 mutations. Methanethiol oxidase deficiency causes cabbage-like breath odor (extraoral halitosis). The association of mercaptopyruvate sulfur transferase deficiency with cognitive impairment, as the only disease characteristic, is questionable. Isolated sulfite oxidase deficiency is characterized by refractory convulsions in early infancy, brain atrophy, severe psychomotor retardation, and lens dislocation. Ethylmalonic encephalopathy is a severe disorder manifesting with seizures, developmental delay and cognitive impairment, orthostatic acrocyanosis and petechia due to vasodilation, failure to thrive, and chronic hemorrhagic diarrhea. Measurement of plasma and urine amino acids and total homocysteine can detect many of the disorders described in this chapter, while other tests are necessary for others. Confirmatory tests are enzyme assays and/or mutation analysis. Treatment combines one or more of dietary restriction of precursors, substitution of essential products, pharmacologic doses of cofactors, and binding and removing of harmful metabolites. Early diagnosis and early treatment favor better outcome.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
<a href="/en/project/NV16-30384A" target="_blank" >NV16-30384A: Metabolism of organic and inorganic sulfur compounds in selected human diseases</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases
ISBN
978-3-030-67726-8
Number of pages of the result
26
Pages from-to
365-390
Number of pages of the book
1534
Publisher name
Springer
Place of publication
Cham
UT code for WoS chapter
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