Management of apixaban anticoagulation in a patient requiring therapeutic plasma exchange: a case report and a literature review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F24%3A10484642" target="_blank" >RIV/00064165:_____/24:10484642 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10484642
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7JKANYxaW~" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7JKANYxaW~</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1691/ph.2024.4550" target="_blank" >10.1691/ph.2024.4550</a>
Alternative languages
Result language
angličtina
Original language name
Management of apixaban anticoagulation in a patient requiring therapeutic plasma exchange: a case report and a literature review
Original language description
Therapeutic plasma exchange (TPE) is used as an effective treatment modality for a variety of autoimmune disorders. Apart from its desired effect of removing pathological blood components, it also can remove coagulation factors and drugs. Currently, there is an insufficient amount of information regarding the use of direct oral anticoagulants in this setting. In this article, we present a case report of a patient with myasthenia gravis and chronic anticoagulation with apixaban who underwent a series of TPE while continuing apixaban treatment. We observed that only 10 % of daily dose was removed by the procedure and plasma levels of apixaban corresponded with expected range. TPE was not associated with shortened drug plasma half-life. We did not observe any significant alteration of apixaban pharmacokinetics during the period of TPE therapy, as well as no thrombotic or bleeding events. This case report supports the use of apixaban in patients treated by TPE, nevertheless, to firmly establish apixaban efficacy and safety profile in this clinical setting further research is needed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Die Pharmazie
ISSN
0031-7144
e-ISSN
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Volume of the periodical
79
Issue of the periodical within the volume
7-8
Country of publishing house
DE - GERMANY
Number of pages
4
Pages from-to
159-162
UT code for WoS article
001304779300004
EID of the result in the Scopus database
2-s2.0-85201592043