Bruton's Tyrosine Kinase: A Potential Novel Target for Neurological Disorders

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10499783" target="_blank" >RIV/00064165:_____/25:10499783 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10499783 RIV/00216208:11310/25:10499783
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=B7.dUfS1zj" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=B7.dUfS1zj</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.935494" target="_blank" >10.33549/physiolres.935494</a>

Result language
angličtina
Original language name
Bruton's Tyrosine Kinase: A Potential Novel Target for Neurological Disorders
Original language description
Bruton's tyrosine kinase (BTK) is a crucial part of the B-cell receptor signaling pathway that has been extensively studied in various types of malignancies. Recent studies have extended our knowledge on its role in metabolism as well as neurological disorders. It may play an important role in the pathophysiology of neurological diseases, such as multiple sclerosis, Alzheimer's disease, brain injury, and several others. Activation of inflammasomes, mainly NLRP3, is one of the core mechanisms by which it promotes inflammation in the brain related to aging and diseases. In this paper, we provide an overview of the less explored roles of BTK in several brain diseases and discuss the potential of its inhibition to become a therapeutic target for neurological diseases.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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