Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F20%3A00078396" target="_blank" >RIV/00209805:_____/20:00078396 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41588-020-0610-9#article-info" target="_blank" >https://www.nature.com/articles/s41588-020-0610-9#article-info</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41588-020-0610-9" target="_blank" >10.1038/s41588-020-0610-9</a>
Alternative languages
Result language
angličtina
Original language name
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease
Original language description
Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson's disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson's disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature genetics
ISSN
1061-4036
e-ISSN
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Volume of the periodical
52
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
482-493
UT code for WoS article
000529000400002
EID of the result in the Scopus database
2-s2.0-85084195663