Added value of serum proteins to clinical and ultrasound information in predicting the risk of malignancy in ovarian tumors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10505137" target="_blank" >RIV/00064165:_____/25:10505137 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10505137
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=j2nq8Z8Tk0" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=j2nq8Z8Tk0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.isci.2025.113725" target="_blank" >10.1016/j.isci.2025.113725</a>
Alternative languages
Result language
angličtina
Original language name
Added value of serum proteins to clinical and ultrasound information in predicting the risk of malignancy in ovarian tumors
Original language description
Assessment of Different Neoplasias in the Adnexa (ADNEX) is the best-performing model to estimate the risk of malignancy in ovarian tumors. We assessed the incremental value of serum proteins over ADNEX predictors in an exploratory multicenter study. In a cohort of 932 patients with an adnexal mass scheduled for surgery, 33 serum proteins were preoperatively quantified using multiplex high-throughput and electrochemiluminescence immunoassays. Using multivariable logistic regression, ADNEX predictors alone had an area under the receiver operating characteristic curve (AUC) of 0.91 (95% confidence interval, 0.89-0.93) to discriminate benign from malignant tumors. This AUC increased most after adding HE4 (+0.03) or CA125 (+0.02). CA72.4 increased AUCs to discriminate secondary metastatic tumors from benign (+0.03), borderline (+0.03), and stage I tumors (+0.03). CA15.3 increased AUCs to discriminate borderline tumors from stage I (+0.01) and stage II-IV tumors (+0.03). While CA125 and HE4 had the highest added value over ADNEX predictors, CA72.4 and CA15.3 may improve discrimination between malignant subtypes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
iScience
ISSN
2589-0042
e-ISSN
2589-0042
Volume of the periodical
28
Issue of the periodical within the volume
11
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
17
Pages from-to
113725
UT code for WoS article
001607289300001
EID of the result in the Scopus database
2-s2.0-105020267834