High-dose immunoablation with autologos haematopoietic cell transplantation in aggressive multiple sclerosis: a single 10-year experience

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F10%3A%230000053" target="_blank" >RIV/00064173:_____/10:#0000053 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

High-dose immunoablation with autologos haematopoietic cell transplantation in aggressive multiple sclerosis: a single 10-year experience

Original language description

There are multiple sclerosis patiens who suffer from an aggressive course of the disease with severe relapses and rapid accumulation of disability adeqate treatment. In such cases high-dose immunoablation with autologuous haematopoietic stem cell transplantation (ASCT) may be considered. Our objective was toreport our experience with 26 multiple sclerosis patients treated with ASCT within the years 1998-2008. Twenty-six patients (Expanded Disability Status Scale 2.5-7.5 (median 6.0), multiple sclerosisduration 2-19 years (median 7) with aggresive multiple sclerosis underwent autologous haematopoietic stem cell transplantation. Stem cells were mobilized by high-dose cyclophosphamide and granulocyte colony-stimulating factor, BEAM( carmustine, cytarabine, melphalan) was used for immunoablation. Patients were evaluated at baseline and every six months post ASCT for adverse events and clinicaloutcome.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

<a href="/en/project/NR9375" target="_blank" >NR9375: The role of autologous haematopoetic stem cells in neuroprotection and immunomodulation in malignant multiple sclerosis</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Multiple Sclerosis

ISSN

1352-4585

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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