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The effect of selected pre-analytical phase variables on plasma thromboxane A2 measurements in humans

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F13%3A%230000350" target="_blank" >RIV/00064173:_____/13:#0000350 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1111/j.1751-553X.2012.01458.x" target="_blank" >http://dx.doi.org/10.1111/j.1751-553X.2012.01458.x</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/j.1751-553X.2012.01458.x" target="_blank" >10.1111/j.1751-553X.2012.01458.x</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The effect of selected pre-analytical phase variables on plasma thromboxane A2 measurements in humans

  • Original language description

    Aims: Platelet function testing is often affected by the existence of different pre-analytical variables that can cause platelet activation. The aim of this study was to assess the effect of such variables that are present when samples are taken (different anticoagulants, incubation temperature, and storage conditions) to select those which enable to reach optimal range of measured plasma concentrations of the two stable thromboxane A2 metabolites, that is, thromboxane B2 (TxB2) and 11-dehydrothromboxane B2 (11-dTxB2). Materials and Methods: For the purpose of this study, whole blood samples obtained from 20 volunteers were screened for TxB2 and 11-dTxB2 concentrations using commercial EIA kits (Cayman Chemicals; Neogen) in relation to the effect of different anticoagulants, using different incubation temperatures and storage conditions. Results:Trisodium citrate has been shown not to be affecting the TxB2 and 11-dTxB2 concentrations compared with the values measured in the serum. Incu

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Scandinavian Journal of Clinical & Laboratory Investigation

  • ISSN

    0036-5513

  • e-ISSN

  • Volume of the periodical

    35

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

    92-100

  • UT code for WoS article

    000316146100018

  • EID of the result in the Scopus database