The effect of selected pre-analytical phase variables on plasma thromboxane A2 measurements in humans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F13%3A%230000350" target="_blank" >RIV/00064173:_____/13:#0000350 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1751-553X.2012.01458.x" target="_blank" >http://dx.doi.org/10.1111/j.1751-553X.2012.01458.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1751-553X.2012.01458.x" target="_blank" >10.1111/j.1751-553X.2012.01458.x</a>
Alternative languages
Result language
angličtina
Original language name
The effect of selected pre-analytical phase variables on plasma thromboxane A2 measurements in humans
Original language description
Aims: Platelet function testing is often affected by the existence of different pre-analytical variables that can cause platelet activation. The aim of this study was to assess the effect of such variables that are present when samples are taken (different anticoagulants, incubation temperature, and storage conditions) to select those which enable to reach optimal range of measured plasma concentrations of the two stable thromboxane A2 metabolites, that is, thromboxane B2 (TxB2) and 11-dehydrothromboxane B2 (11-dTxB2). Materials and Methods: For the purpose of this study, whole blood samples obtained from 20 volunteers were screened for TxB2 and 11-dTxB2 concentrations using commercial EIA kits (Cayman Chemicals; Neogen) in relation to the effect of different anticoagulants, using different incubation temperatures and storage conditions. Results:Trisodium citrate has been shown not to be affecting the TxB2 and 11-dTxB2 concentrations compared with the values measured in the serum. Incu
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scandinavian Journal of Clinical & Laboratory Investigation
ISSN
0036-5513
e-ISSN
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Volume of the periodical
35
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
92-100
UT code for WoS article
000316146100018
EID of the result in the Scopus database
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