The Decrease in Number and Change in Phenotype of Mucosal-Associated Invariant T cells in the Elderly and Differences in Men and Women of Reproductive Age

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F14%3AN0000041" target="_blank" >RIV/00064173:_____/14:N0000041 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/sji.12193" target="_blank" >http://dx.doi.org/10.1111/sji.12193</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/sji.12193" target="_blank" >10.1111/sji.12193</a>

Result language

angličtina

Original language name

The Decrease in Number and Change in Phenotype of Mucosal-Associated Invariant T cells in the Elderly and Differences in Men and Women of Reproductive Age

Original language description

Mucosal associated invariant T (MAIT) cells are innate-like T cells comprising up to 10% of the peripheral blood T cells in humans. During ontogeny, MAIT cells can first be detected in the cord blood in low amounts, but rise steadily after birth. In this population-based study, we show that their counts continue to increase, reaching maximal levels (4.5% of CD3+ cells, 65 cells/μl) in the third and fourth decenniums. At this age, the amounts of MAIT cells exhibit the highest inter-individual variability. The values then dramatically decline; subjects 80 years old and older have on average 10 times less MAIT cells, both absolutely and as a percentage among CD3+ T cells, than subjects in fertile age. The senescence of MAIT cells is associated with decreased CD8/double negative (DN) ratio. Finally, we observed significantly higher amounts of MAIT cells in females of reproductive age than in males of the same age. Our data suggests that further studies aimed at elucidating a role of MAIT cells in human pathologies must recruit age- and gender- matched controls.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scandinavian Journal of Immunology

ISSN

0300-9475

e-ISSN

1365-3083

Volume of the periodical

80

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

271-275

UT code for WoS article

000342687500004

EID of the result in the Scopus database

2-s2.0-84907830208