The influence of age on clinical outcomes in patients treated with the resolute zotarolimus-eluting stent
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000001" target="_blank" >RIV/00064173:_____/16:N0000001 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/16:43908129
Result on the web
<a href="http://dx.doi.org/10.1002/ccd.25334" target="_blank" >http://dx.doi.org/10.1002/ccd.25334</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ccd.25334" target="_blank" >10.1002/ccd.25334</a>
Alternative languages
Result language
angličtina
Original language name
The influence of age on clinical outcomes in patients treated with the resolute zotarolimus-eluting stent
Original language description
Aims: To evaluate the rate of clinical events and bleeding risk according to age in patients undergoing percutaneous coronary intervention (PCI) with new-generation drug-eluting stent enrolled in the RESOLUTE Global Clinical Program. Methods: This study represents a pooled analysis of 5 trials included in the RESOLUTE program including 5,130 patients, of whom 1675 (32.6%) were GREATER-THAN OR EQUAL TO70 years old (elderly patients). Results: After adjusting for confounders, age GREATER-THAN OR EQUAL TO70 years was a significant predictor of high mortality at 30 days (0.6% vs. 0.1%, P = 0.017) and two years (7.2% vs. 2%, P < 0.001). No differences were seen with respect to acute myocardial infarction (MI) or target lesion and vessel revascularization rates between young and elderly patients. Bleeding rates were higher in the elderly throughout follow-up. In the elderly, 7 out of 27 (26%) patients with bleeding episodes died, with a median time between bleeding episode to death of 21 days. In the younger population, 1 patient out of 17 with bleeding episode died (400 days later). Conclusion: Elderly patients undergoing PCI with a new-generation drug-eluting stent have an increased mortality and bleeding risk, with similar rates of acute MI and repeat revascularization. Bleeding risk was higher in the elderly and strongly related to death. TLF rates were not significantly different between the 2 age groups suggesting that the R-ZES is effective for patients younger and older than 70 years of age. R-ZES may be recommended for elderly patients when PCI with a DES is identified as a suitable option.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Catheterization & Cardiovascular Interventions
ISSN
1522-1946
e-ISSN
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Volume of the periodical
87
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
253-261
UT code for WoS article
000370451700018
EID of the result in the Scopus database
2-s2.0-84959482474