Electrophysiological and histological changes of paraspinal muscles in adolescent idiopathic scoliosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000020" target="_blank" >RIV/00064173:_____/16:N0000020 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/16:10332485 RIV/00216208:11120/16:43911651 RIV/00064203:_____/16:10332485

Result on the web

<a href="http://dx.doi.org/10.1007/s00586-016-4628-8" target="_blank" >http://dx.doi.org/10.1007/s00586-016-4628-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00586-016-4628-8" target="_blank" >10.1007/s00586-016-4628-8</a>

Result language

angličtina

Original language name

Electrophysiological and histological changes of paraspinal muscles in adolescent idiopathic scoliosis

Original language description

PURPOSE: The pathogenesis of adolescent idiopathic scoliosis (AIS) remains poorly understood. To date, potentially involved local changes in the deep paraspinal muscles still remain unknown. METHODS: Needle electromyography (EMG) and muscle biopsy of paraspinal muscles at convexity and concavity of the AIS main thoracic curve were performed in 25 subjects. In this group, EMG was performed in 16 AIS subjects (12 females, 12-27 years), muscle biopsy in 18 AIS subjects (15 females, 11-31 years) compared to 10 non-scoliotic controls (6 females, 12-55 years). Samples of muscle tissue were removed during corrective surgery and were examined histologically, enzyme histochemically and immunohistochemically. Both methods of EMG and muscle biopsy were performed in 9 subjects (7 women, 12-27 years). RESULTS: Right curve convexity was found in 24 AIS subjects. Amplitudes of motor unit action potentials (MUPs) were significantly increased on the AIS curve convexity versus concavity. Turns, duration and phases of MUPs were without any significant changes. In all 18 subjects, the histological examination revealed muscle fiber redistribution with numerical predominance of type I on the curve convexity which strongly correlated with the progression of the Cobb angle. CONCLUSION: Our findings demonstrate significant changes of muscle fiber redistribution in the paraspinal muscles of AIS with increased proportion of type I on the convexity corresponding to a significantly higher amplitude of MUPs on the same side. A possible explanation of this alteration is a secondary adaptation due to chronic high load demand.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NT13693" target="_blank" >NT13693: Morphological, histochemical and electrophysiological changes in the chest wall muscles in patients with idiopathic scoliosis and their potential role in the etiopathogenesis of the disease.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Spine Journal

ISSN

0940-6719

e-ISSN

—

Volume of the periodical

25

Issue of the periodical within the volume

10

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

3146-3153

UT code for WoS article

000385186100018

EID of the result in the Scopus database

2-s2.0-84973163849