A product of immunoreactive trypsinogen and pancreatitis-associated protein as second-tier strategy in cystic fibrosis newborn screening

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000035" target="_blank" >RIV/00064173:_____/16:N0000035 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/16:10332816 RIV/00216208:11120/16:43912047 RIV/00064203:_____/16:10332816
Result on the web
<a href="http://dx.doi.org/10.1016/j.jcf.2016.07.002" target="_blank" >http://dx.doi.org/10.1016/j.jcf.2016.07.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcf.2016.07.002" target="_blank" >10.1016/j.jcf.2016.07.002</a>

Result language
angličtina
Original language name
A product of immunoreactive trypsinogen and pancreatitis-associated protein as second-tier strategy in cystic fibrosis newborn screening
Original language description
Background: In cystic fibrosis newborn screening (CFNBS), immunoreactive trypsinogen (IRT) and pancreatitis-associated protein (PAP) can be used as screening parameters. We evaluated the IRT. x. PAP product as second-tier parameter in CFNBS in newborns with elevated IRT. Methods: Data on 410,111 screened newborns including 78 patients with classical cystic fibrosis (CF) from two European centers were retrospectively analyzed by discrimination analysis to identify a screening protocol with optimal cutoffs. We also studied differences in PAP measurement methods and the association of IRT and PAP with age. Results: PAP values differed systematically between fluorometric and photometric assays. The IRT. x. PAP product showed better discrimination for classical CF than PAP only as second-tier screening parameter (p . <. 0.001). In CF patients, IRT decreased while PAP values remained high over years. In newborns without CF, IRT decreased after birth over weeks while PAP increased within days. Conclusions: The IRT. x. PAP product performs well as second-tier cutoff parameter for CFNBS. Screening quality parameters depend on the analytic method and on age at blood collection.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FG - Paediatrics
OECD FORD branch
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Project
<a href="/en/project/LM2015091" target="_blank" >LM2015091: National Center for Medical Genomic</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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