Analysis of the Phenotype and Function of the Subpopulations of Mucosal-Associated Invariant T Cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000120" target="_blank" >RIV/00064173:_____/16:N0000120 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/16:43912046

Result on the web

<a href="http://dx.doi.org/10.1111/sji.12467" target="_blank" >http://dx.doi.org/10.1111/sji.12467</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/sji.12467" target="_blank" >10.1111/sji.12467</a>

Result language

angličtina

Original language name

Analysis of the Phenotype and Function of the Subpopulations of Mucosal-Associated Invariant T Cells

Original language description

Mucosal-associated invariant T (MAIT) cells contain two main subpopulations, CD8+ and double negative (DN) cells. The first reports suggested that subpopulations of MAIT cells have similar phenotype and function. Recent works, however, demonstrate that the subpopulations have different ontogenesis and are differentially affected by xenobiotic treatment. In this work we reexamined the possible differences between subpopulations of MAIT cells. We demonstrate that the main subpopulations of MAIT cells (CD8 and DN) are relatively uniform both in terms of phenotype and function. Both populations are memory/activated, tissue homing, and pro-inflammatory. CD8+ MAIT cells are better equipped for pro-inflammatory functions as they express higher levels of CD16 and NKG2D, produce more pro-inflammatory cytokines (TNF-α and IFN-γ), and have higher cytotoxic potential (contain more Granzyme B and express higher levels of CD107A upon stimulation). Our study contributes to the understanding of the heterogenity of MAIT cell population.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scandinavian Journal of Immunology

ISSN

0300-9475

e-ISSN

—

Volume of the periodical

84

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

245-251

UT code for WoS article

000387048700007

EID of the result in the Scopus database

2-s2.0-84988632601