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Circulating Endometrial Cells in Women With Spontaneous Pneumothorax

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F19%3AN0000030" target="_blank" >RIV/00064173:_____/19:N0000030 - isvavai.cz</a>

  • Alternative codes found

    RIV/61383082:_____/20:00000964 RIV/00216208:11110/20:10402507 RIV/00216208:11120/20:43918760 RIV/00064203:_____/20:10402507

  • Result on the web

    <a href="https://doi.org/10.1016/j.chest.2019.09.008" target="_blank" >https://doi.org/10.1016/j.chest.2019.09.008</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.chest.2019.09.008" target="_blank" >10.1016/j.chest.2019.09.008</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Circulating Endometrial Cells in Women With Spontaneous Pneumothorax

  • Original language description

    BACKGROUND: The occurrence of catamenial pneumothorax (CP) is rare and the awareness of this diagnosis among clinicians is insufficient. CP is highly correlated with pelvic endometriosis and remains the most common form of thoracic endometriosis syndrome. Circulating Endometrial Cells (CECs) were previously detected in patients with pelvic endometriosis. Could CECs bring new insights into pneumothorax management? METHODS: The presented study aims to describe the occurrence and molecular characteristics of CECs in women with spontaneous pneumothorax (SP) (n= 20) with high suspicion of its catamenial character. CECs were enriched from peripheral blood by size-based separation (MetaCell(R)). In addition to cytomorphology, gene expression profiling of captured cells was performed for 24 endometriosis associated genes. RESULTS: CECs were present in all 20 patients with SP. Enriched CECs exhibited four character features: epithelial, stem -cell like, stroma-like, and glandular. However, not all of them were present in every sampling. Gene expression profiling revealed two distinct phenotypes of CECs in SP/CP, whereby one of them refers to the diaphragm openings syndrome and the second to the endometrial tissue pleural implantations. Comparisons of the gene expression profiles of CECs in pneumothorax (CECs-SP) with CECs in pelvic endometriosis (CECs-non-SP) have revealed significantly higher expression of HER2 in CECs-SP compared to CECs-non-SP. CONCLUSION: This proof of concept study demonstrates successful isolation and characterization of CECs in patients with SP. Identification of CECs in SP could alert endometriosis involvement and help early referral to gynecologic consultation for further examination and treatment.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Chest

  • ISSN

    0012-3692

  • e-ISSN

    1931-3543

  • Volume of the periodical

    157

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    14

  • Pages from-to

    342-355

  • UT code for WoS article

    000512414700023

  • EID of the result in the Scopus database

    2-s2.0-85078156205