Hypoglycemia and antihyperglycemic treatment in adult MODY patients - a systematic review of literature

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F19%3AN0000118" target="_blank" >RIV/00064173:_____/19:N0000118 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/19:43919128 RIV/00216208:11130/19:10401876 RIV/00064203:_____/19:10401876

Result on the web

<a href="https://doi.org/10.1016/j.diabres.2019.107914" target="_blank" >https://doi.org/10.1016/j.diabres.2019.107914</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.diabres.2019.107914" target="_blank" >10.1016/j.diabres.2019.107914</a>

Result language

angličtina

Original language name

Hypoglycemia and antihyperglycemic treatment in adult MODY patients - a systematic review of literature

Original language description

Maturity onset diabetes of the young (MODY) is a heterogeneous group of diseases caused by a single mutation in one of the 14 genes involved in the regulation of glucose homeostasis. GCK, HNF1A, and HNF4A genes are among the most common genes affected. Expression of these genes in the key organs for defense against hypoglycemia and their participation in counter-regulation to hypoglycemia may potentially put individuals with a heterozygous mutation in these genes at increased risk for hypoglycemia. In HNF4A-MODY and HNF1A-MODY patients, normal or even increased insulin sensitivity together with glucose-independent mechanism of action of the first-line therapy - sulphonylurea derivatives - often leads to hypoglycemia, even at the much lower dose used in type 2 diabetes. This review aims to analyze clinical studies and case reports concerning hypoglycemia associated with antihyperglycemic treatment in adult MODY patients.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diabetes Research and Clinical Practice

ISSN

0168-8227

e-ISSN

1872-8227

Volume of the periodical

158

Issue of the periodical within the volume

December

Country of publishing house

IE - IRELAND

Number of pages

9

Pages from-to

Article 107914

UT code for WoS article

000501999600017

EID of the result in the Scopus database

2-s2.0-85075305580